Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine
نویسندگان
چکیده
منابع مشابه
Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine
Modified nucleobase analogues can serve as powerful tools for changing physicochemical and biological properties of DNA or RNA. Guanosine derivatives containing bulky substituents at 8 position are known to adopt syn conformation of N-glycoside bond. On the contrary, in RNA the anti conformation is predominant in Watson-Crick base pairing. In this paper two 8-substituted guanosine derivatives, ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0137674